News and press releases
SkylineDx Receives Notice of Allowance to Grant Patent for Prognostic SKY92 Gene Signature in Japan
The Japanese Patent Office Has Notified SkylineDx of the Decision to Grant a Patent for the SKY92 Gene Signature
Rotterdam, the Netherlands, Laguna Hills, CA, Tokyo, Japan, October 11, 2016 - SkylineDx is pleased to announce that it has received a notice of allowance for a Japanese patent related to its prognostic SKY92 gene signature for multiple myeloma. The announcement comes as SkylineDx prepares to attend the 78th Annual Meeting of the Japanese Society of Hematology (JSH2016) in Pacifico Yokohama, October 13 -15, 2016.
The SKY92 signature consists of 92 genes that are informative of outcome related to multiple myeloma, the combined expression level of which can be measured using MMprofiler, the lead product of SkylineDx. Clinicians can use MMprofiler with SKY92 results to predict for their patients how multiple myeloma is likely to progress and assist with determining the optimal treatment for the patient.
The patent is part of a larger patent family, since SkylineDx has sought broad patent protection for the SKY92 gene signature. The patent was originally filed by the Erasmus Medical Center in 2012, upon discovery of SKY92 within the hematology department. Later, SKY92 was licensed exclusively to SkylineDx, which now solely has the global rights to the gene signature.
“SkylineDx is pleased to have received this notice of allowance from the Japanese Patent Office for our SKY92 gene signature, which is another step forward in our mission to provide clinicians with the tools needed to help personalize treatment plans.” said Dharminder S. Chahal, Chief Executive Officer of SkylineDx. “With a number of our patents already granted worldwide, this patent in Japan is yet another key milestone in our commercial efforts to expand our global presence.”
About Multiple Myeloma
Multiple myeloma (MM) is a cancer that arises from plasma cells, a type of white blood cell made in the bone marrow. In patients with MM, the plasma cells become abnormal, multiply uncontrollably, and release only one type of antibody – known as M-protein – which has no useful function. It is often through the measurement of M-protein that MM is diagnosed and monitored. Most medical problems related to MM are caused by the build-up of abnormal plasma cells in the bone marrow and the presence of the M-protein in the blood or urine. The most common symptoms of MM include bone pain, recurring infection, kidney damage, and fatigue. According to the World Cancer Research Fund International, an estimated 114,000 people around the world are diagnosed with MM annually, and the disease represents 0.8% of all cancers globally.
For more information about MM, visit www.hematon.nl/myeloom (information available in Dutch only), www.themmrf.org, www.myeloma.org.uk, www.mpeurope.org, www.myeloma.org, and www.jsm.gr.jp.
MMprofiler with SKY92 is the only gene-based signature proven superior to the biomarkers currently used to risk stratify newly diagnosed and relapsed multiple myeloma patients into a “high” or “standard” risk category1. MMprofiler is CE-IVD registered and available in Europe and is coming soon as a laboratory developed test (LDT) in the United States.
For more information, please visit www.mmprofiler.com.
SkylineDx is a commercial-stage biotech company based in Rotterdam, the Netherlands. Originally a spin-off of the Erasmus Medical Center in Rotterdam, the company specializes in the development and marketing of innovative gene signature based diagnostic tests to assist healthcare professionals in making personalized treatment decisions for individual patients. These tests are designed to accurately determine the type or status of the disease or to predict a patient’s response to a specific treatment. Based on the test results, healthcare professionals can tailor the treatment to the individual patient. MMprofiler is the company’s lead product. To learn more, please visit www.skylinedx.com.
Media Inquiries for SkylineDx
Jeffrey Jones, SkylineDx
John Kouten, JFK Communications, Inc.
1. Van Beers EH, et al. SKY92 GEP, iFISH, and ISS comparisons for risk stratification in multiple myeloma. Poster p661 presented at 2015 European Hematology Association Congress.
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- SkylineDx Poster Presentations at ASH Meeting Further Validate Use of MMprofiler™ with SKY92 in Multiple Myeloma
- SKY92 Gene Signature Facilitates Cost-effective, Risk-stratified Treatment of Multiple Myeloma
- SkylineDx Announces Prognostic Tool to be Used as Part of Major New Myeloma Clinical Trial
- SkylineDx Researchers Publish Data Demonstrating Utility of SKY92 as Prognostic Tool in Multiple Myeloma (MM)
- SkylineDx Presented New Algorithm Demonstrating Ability to Successfully Identify Gene Sets that are Informative of Cancer Treatment Specific Survival
- SkylineDx Announces Multiple Studies Being Presented at the 58th Annual ASH Meeting Reinforcing Utility of MMprofiler™ Gene-Based Prognostic Signature to Impact Treatment of Patients with Multiple Myeloma
- SkylineDx Receives Notice of Allowance to Grant Patent for Prognostic SKY92 Gene Signature in Japan
- SkylineDx and Consortium of Leading European Partners awarded multi-million Euro Horizon2020 grant from European Commission
- SkylineDx to Present New Data Demonstrating MMprofiler™ as Robust Prognostic Tool in Multiple Myeloma at the European Hematology Association 21st Annual Congress (EHA)
- SkylineDx Supports Myeloma Awareness Month to Raise Awareness of a Serious and Difficult to Treat Disease
- SkylineDx to Present New Data Demonstrating Prognostic Value of MMprofiler™ in Multiple Myeloma at American Society of Hematology Annual Meeting
- SkylineDx Receives CE-IVD Mark for MMprofiler™ Its Innovative Gene Signature-Based Test for Multiple Myeloma
- SKY92-ISS Superior to current markers in risk classification for myeloma survival
- SkylineDx appoints Leonard Kruimer as CFO Peter Schineller as CCO
- More Accurate Prediction on Prognosis in Multiple Myeloma (bone marrow cancer)
- SkylineDx Presents an Abstract on Risk Identification for Multiple Myeloma Patients at the 20th Congress of the EHA
04 Jan 2018 - 04 Jan 2018, UCI Medical Center, Orange, California USA
Orange County Multiple Myeloma Support Group
SkylineDx Regional Business Manager, Americas, Patricia Murphy will give a brief overview of SKY92. Account Manager A.J. Sura will also be in attendance.
08 Jan 2018 - 11 Jan 2018, San Francisco, Clifornia, USA
J.P. Morgan 36th Annual Healthcare Conference
SkylineDx CEO Dharminder Chahal will be in attendance at this conference.
24 Jan 2018 - 25 Jan 2018, Papendal, Arnhem, The Netherlands
Dutch Hematology Congress
SkylineDx EVP of Genomics, Erik van Beers and Jolien van Leijen, Account Manager will be in attendance at this congress.
22 Mar 2018 - 24 Mar 2018, Rosen Shingle Creek, Orlando Florida, USA
NCCN 23rd Annual Conference
SkylineDx will be represented at this conference by Regional Business Manager, Patricia Murphy.
28 Mar 2018 - 30 Mar 2018, Radboud University Medical Center, Nijmegen, The Netherlands
6th International Workshop on Cancer Genetic & Cytogenetic Diagnostics
SkylineDx will be represented at this conference by Jolien van Leijen, Account Manager.